Description
An S1P2 and S1P4 receptor antagonist (IC50 = 17 and 237 nM, respectively); selective for S1P2 over S1P1 and S1P3 (IC50s = >10 µM for both); reverses S1P-induced inhibition of HUVEC and SMC migration at 1 and 10 µM; reverses S1P-induced inhibition of B16 murine melanoma cell migration; reduces lung injury, endothelial dysfunction, and pulmonary edema in a rat model of cecal ligation and puncture-induced sepsis at 30 mg/kg; inhibits DES1 (IC50 = 16.8 µM), as well as SK1 and SK2 (IC50s = 25.1 and 4.3 µM, respectively)